Spravato® (esketamine) Nasal Spray for
Depression at Junction Brain Health
An FDA-approved intranasal ketamine treatment for adults with treatment-resistant
depression.
What is Spravato® (Esketamine)?
Spravato® (esketamine) nasal spray is the first FDA-approved intranasal ketamine option for adults with treatment-resistant depression (TRD). It can also be used with an oral antidepressant to treat major depressive disorder (MDD) with suicidal thoughts or actions.
Who Can Benefit From Spravato® Treatment
depression after trying 2+
antidepressants
Adults with major depressive disorder (MDD) with suicidal thoughts (with oral antidepressant)
Patients seeking care at a certified Spravato® treatment center under full medical supervision
How Spravato® Treatment Works –
What to Expect
- Schedule a consultation at our Spravato® treatment center.
- Our team reviews your medical history, treatment goals, and insurance.
- No medication is given at the first visit.
Day of Treatment
- You self-administer Spravato® intranasal ketamine under medical supervision.
- Monitored for 2 hours (blood pressure, oxygen, side effects).
After Treatment
- No driving or machinery until the next day.
- Typical schedule: 2x/week (Month 1), 1x/week (Month 2), then adjusted with your provider.
- Spravato® for depression cannot be self-administered at home.
Is Spravato® Covered by Insurance?
Our staff works directly with your insurance to verify coverage and
out-of-pocket costs before treatment begins.
Patient-Centered Care
Our doctors and nurses coordinate with your referring provider.
Continuous monitoring and personalized treatment adjustments.
A dedicated care team guiding you every step of the journey.
SPRAVATO® is an FDA-approved nasal spray for adults with treatment-resistant depression (when two or more antidepressants haven’t worked) and for adults with major depression with suicidal thoughts or actions, taken alongside an oral antidepressant.
TMS treats depression at its source. A patient sits in a chair similar to that in a dentist’s office, and a paddle containing a magnetic coil is positioned over the left dorsolateral prefrontal cortex on a patient’s head (the left side just above the forehead). That is the area of the brain known to be involved in mood regulation. In depressed patients, that area is shown to be underactive compared to non-depressed patients.
The coil transmits magnetic pulses that gently correct abnormally firing circuits in the brain. By targeting a major hub for mood, the left dorsolateral prefrontal cortex, TMS affects the entire brain’s mood network, generating positive, long-lasting results.
You’ll spray SPRAVATO® yourself under supervision, then stay at the clinic for monitoring. Because of possible side effects like sleepiness or dizziness, you cannot drive until the next day after a full night’s rest, so arrange for a ride home.
TMS treats depression at its source. A patient sits in a chair similar to that in a dentist’s office, and a paddle containing a magnetic coil is positioned over the left dorsolateral prefrontal cortex on a patient’s head (the left side just above the forehead). That is the area of the brain known to be involved in mood regulation. In depressed patients, that area is shown to be underactive compared to non-depressed patients.
The coil transmits magnetic pulses that gently correct abnormally firing circuits in the brain. By targeting a major hub for mood, the left dorsolateral prefrontal cortex, TMS affects the entire brain’s mood network, generating positive, long-lasting results.
Most patients begin with two treatments per week for the first month, then move to once per week in the second month. After that, you and your provider decide the right schedule for your ongoing care.
The most common effects include dizziness, nausea, sleepiness, increased blood pressure, feeling “disconnected,” or a temporary drunk-like sensation. These usually happen soon after treatment and fade the same day.
TMS treats depression at its source. A patient sits in a chair similar to that in a dentist’s office, and a paddle containing a magnetic coil is positioned over the left dorsolateral prefrontal cortex on a patient’s head (the left side just above the forehead). That is the area of the brain known to be involved in mood regulation. In depressed patients, that area is shown to be underactive compared to non-depressed patients.
The coil transmits magnetic pulses that gently correct abnormally firing circuits in the brain. By targeting a major hub for mood, the left dorsolateral prefrontal cortex, TMS affects the entire brain’s mood network, generating positive, long-lasting results.
Frequently Asked Questions
Important Safety Information
Audiences and conditions, such as:
Sedation, dissociation, respiratory depression risks
Abuse/misuse potential
REMS program requirement
Contraindications: aneurysmal vascular disease, brain bleeding history, allergy to ketamine/
esketamine
Common side effects: dizziness, nausea, sleepiness, increased blood pressure, headache
Sedation, dissociation, respiratory depression risks
Abuse/misuse potential
REMS program requirement
Contraindications: aneurysmal vascular disease, brain bleeding history, allergy to ketamine/esketamine
Common side effects: dizziness, nausea, sleepiness, increased blood pressure, headache